For gastric ulcer discuss “saying”
Ulcer disease etiology and pathogenesis of more complex, so far inconclusive. Since the last century, the world of ulcer disease etiology and pathogenesis are conducting continuous research and study, and have dozens of theories, but still achieve the same understanding of the end. Now several major theories are described below:
(1) trauma theory: Some people think that the stomach and duodenal ulcer formation of primary injury is the reason. The damage factors are mechanical, thermal, chemical nature of the stimulus. The stimulation gastric mucosal injury; become “auto-digestion” of the starting point and then develop into ulcers.
The doctrine expounded ulcer disease caused by external causes, it is clear the error is not more important emphasis on internal factors. Should be, those wounds factors, only the external cause, and only through certain internal factors can cause ulcer disease.
(2) vascular theory: Some believe that the stomach in the blood supply to normal, will not be gastric erosion. When the gastrointestinal lesions in blood vessels, so that partial necrosis Erzhi gastric ulcer.
(3) inflammation theory: It was found that 100% of the ulcers at the same time to see the stomach or duodenum mucosal inflammatory lesions, and this lesion occurred in the ulcers prior to the formation. Therefore considers that gastritis is the first stage of the formation of ulcers, followed by the typical ulcer will occur.
(4) digestion theory: We have 100 years of history, it is the increase in the amount of gastric juice, gastric acid and pepsin increased degree of increase in the amount of first place. That such an increase in gastric digestion is a basic factor in ulcer disease occurs. So the old to the disease known as “peptic ulcer.”
However, not all patients with gastric ulcers increased, and some patients with normal or even a lack of stomach acid. Some high-acid were not necessarily ulceration. Therefore, theory has some truth to digest, but can not be explained with the Benbingfasheng related to a variety of complex issues.
(5) The autonomic imbalance theory: autonomic dysfunction and the incidence of ulcer disease have a certain relationship. The fundamental shortcoming of this theory is to underestimate the impact of external environmental conditions, only isolated from the autonomic nervous system to stress the role of this disease, from the impact of the higher nervous activity is clearly one-sided.
(6) The doctrine of cerebral cortex viscera: clinical often due to mental or emotional factors can be seen to occur or worsen ulcer disease cases.
Visceral cortex, the founder of Beike Fu theory that the functional state of the cerebral cortex ulcer disease of disorder is the dominant factor in the process. Cortex activity obstacles, so that the lower part of the cortex and the cortex of normal relations imbalance, leading to sympathetic suppression, tension increased parasympathetic formed ulcers.
(7) infection theory: Since 1983, a new awareness of Helicobacter pylori (referred to as HP), the pathogenesis of peptic ulcer played a fundamental change. Most experts believe that HP is the main reason for peptic ulcer. Seen peptic ulcer should be considered as an infectious disease, in the HP post-eradication, peptic ulcer cure available.
(8) Other theories: In addition to the several doctrines, the doctrine of organized acidosis, vitamin deficiency theory, neurotrophic theory, allergy theory, genetics, said, endocrine theory and so on. These theories have some basis, but there are also many one-sided of the Department.
We believe that the incidence of ulcer disease is not a reason, but a number of factors.
Ulcer is formed, will depend on the factors that contribute to ulcers and resistance ulcers, the outcome of the struggle between the factors.
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