Grasp the medication time to be effective governance of gastric ulcer
Peptic ulcer disease is a common disease, is also an effective cure of the disease, but it is not such a complex and difficult to treat disease, but in the long run afflict thousands of patients. Digestive medicine experts, an important reason for this result, patients with ulcer medication is unscientific, while the medication is unscientific mainly to master use of drugs is not good, kick the tires and the treatment is that treatment is complete.
Experts say the onset of ulcer disease and gastric acid secretion is closely related, so seize the peak of gastric acid secretion and timely medication, improvement of the treatment effect is very important. However, in clinical patients because many ulcers do not know when the best time of medication, leaving drug treatment is not full, resulting in long treatment ulcer disease.
Currently on the market of drugs for the treatment of ulcer disease are two major categories, one is to reduce stomach acid drugs and increasing the defense capability of the gastric and duodenal mucosa of drugs, mainly by alkaline antacids, anti-cholinergic drugs, H2 by the antagonists, proton pump inhibitors, etc.; 2 is to enhance the mucosal defensive ability of drugs, mainly colloidal bismuth, sucralfate and prostaglandins and other drugs.
Alkaline antacids is the first drug for the treatment of ulcer disease can be rapidly and in stomach acid play a significant analgesic effect, and cheap, and to be loved by many patients. Are many kinds of anti-acid drugs, such as baking soda and calcium carbonate and so on, the acid effect of a strong baking soda, a great solubility in the stomach. The advantage is fast-acting analgesic effect is good, but the high doses required to re-use, easy to cause sodium retention and alkali poisoning, it is not long-term use, especially heart and kidney dysfunction in patients with the more necessary to be careful.
Alkaline antacid effect of treatment of peptic ulcer in addition depends on the dose, the key is to master the medication time. Experts say repeated application of antacid medication approach should be taken, that each 1 hour and 3 hours after the meal and before bed time each service, so that the pH value of gastric juice can be kept at 3 or more. This is because the food itself and in stomach acid, so the early postprandial rise in short-term intragastric pH value. However, the physiological food will stimulate gastric acid secretion, generally 1 hour after the meal significantly increased gastric acid secretion, so use this time to take antacids can effectively prevent a decline in the value of intragastric pH. And because the role of antacids usually only 1-2 hours, so three hours after the meal and then serve in a role of antacids in order to maintain the acid. However, due to the human gastric acid secretion is continuous, at night there are gastric acid secretion, thus served time in Canada before going to bed and night benefit in gastric acid secretion, which is particularly suitable for night-time ulcer pain patients, especially patients with duodenal ulcer.
Experts also advise ulcer patients who took anti-acid drugs are clearly related with the meal, we must note that taking the meal, the fasting postprandial worse than the efficacy of medication, because the role of antacids and drugs stay in the stomach to time , fasting medication will soon be discharged from the body, pleasant and in the role of gastric acid. In addition to time, but also with the dose related, with a kind of antacid tablets than powder and agent, so oral tablet should be chewed before the first serve, should not be taking the entire piece.
H2 receptor antagonist treatment of ulcer disease is currently the most widely used drug, it is because it can effectively inhibit gastric acid secretion, ulcer treatment works well. H2 receptor antagonists on gastric ulcer and duodenal ulcer 4 weeks and 6 weeks the cure rate up to 50% to 70%, most patients are medication symptoms of abdominal pain within a week will significantly reduce or disappear. At present the main varieties H2 receptor antagonists cimetidine, ranitidine, famotidine, sediment for the small and Roxatidine so. Experts said that cimetidine should be bedtime dose of 800 mg. Acid between day and night because people have great fluctuations in emissions, generally 5-11 am and lowest at night, the highest secretion, such as the patient can inhibit gastric acid secretion at night while on the treatment of ulcer disease have a very important significance. The use of Ranitidine 150 mg, sooner or later each time; famotidine 20 mg, sooner or later each time. H2 receptor antagonists with fewer side effects, but there are leukopenia, elevated serum transaminases, male sexual dysfunction and breast increased, as well as neuropsychiatric symptoms such as drowsiness, slow, such as hallucinations and agitation.
Proton pump inhibitor is currently the most powerful acid-suppressing agent, is the treatment of ulcer disease heavy weapons, now there are two major clinical applications, one of omeprazole, one is Lansoprazole. Experts say taking time for proton pump inhibitors is also important to grasp, especially drug treatment of certainty, because these drugs have a strong inhibitory effect on gastric acid, long-term use, the patient will continue in a low-acid state, may be affect digestion, gastric emptying in some patients and gall bladder emptying will be contained. Commonly used dose of omeprazole 20 mg once a day treatment course of treatment for 2-4 weeks duodenal ulcer, gastric ulcer treatment for 4-8 weeks. The commonly used dose of lansoprazole 30 mg once a day.
As easy to recurrence of ulcer disease, so the treatment of ulcer disease must grasp two time, that treatment time and the maintenance of remission period. According to experts, for the treatment of ulcers is to reduce gastric acid secretion, but a single course of acid suppression therapy does not change the natural history of ulcer disease in ulcer healing after year, the duodenal ulcer recurrence rate as high as 72% , within half a year ulcer recurrence rate of 42%, but continued treatment can reduce ulcer recurrence rate to 25 percent a year, so the treatment of ulcer disease can not be based solely on time for the healing of ulcers or symptoms until they disappear, but should adhere to maintenance therapy in order to avoid recurrence and thus fall short.
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