Initiator of gastric ulcer

October 13, 2009 · Posted in Causes of gastric ulcers 

Peptic ulcer (including gastric ulcer and duodenal ulcer) causes, long considered to genetics, excess stomach acid, bile reflux, smoking and other factors, in particular in the pathogenesis of gastric acid is considered the main factor. Nearly 80 years, gastric ulcer formation has been regarded as the reason, therefore, have a “no acid no ulcer,” the traditional view.

 Peptic ulcer treatment is the traditional or inhibit gastric acid secretion and gastric acid. The old days of basic drugs, is currently used Hz receptor antagonist, or other gastric acid secretion inhibitors. Application of these acid-fast acid-suppressing drugs, is certainly conducive to the healing of ulcers, but these drugs have a common drawback, once the withdrawal, and soon we spot ulcer recurrence. Therefore, some patients are intermittent medication, and some long-term use Zexu maintenance dose. There are many more patients with ulcer disease has repeatedly made repeatedly.

 Through the gastric analysis shows that patients with duodenal ulcer, gastric acid secretion is too high; and gastric ulcer patients, gastric acid secretion by only 16%, while many patients and normal gastric acid secretion, and some even lower than normal. This shows that the amount of gastric acid secretion is not an important factor in the pathogenesis of gastric ulcer, and gastric mucosal defense capabilities to reduce, so that the role of gastric acid and other attacks on the relative increase may be the main reason for the formation of stomach ulcers.

 In addition, since 1983, a new awareness of the Helicobacter pylori (referred to as HP), the pathogenesis of peptic ulcer, with a new understanding. Most experts believe that HP is one of the factors of peptic ulcer disease, but not the only factor. Patients with gastric ulcer in the past that the higher is the incidence of factors, but now know that HP infection, the gastric antrum HP release of urine due to the formation of enzymes of ammonia, while the ammonia system alkaline, so that secretion of gastrin in gastric antrum G – cells no longer inhibited by the acid, so a large number of gastrin secretion, thus contributing to a large number of parietal cells in the body of stomach acid secretion. So too is the HP infection in gastric acid results. HP will also produce a variety of toxins, and damage to the gastric mucosa from toxic effects. In the gastric ulcer patients, 60% of the Department of HP infection. In the peptic ulcer cases, 95% ~ 100% of ulcer patients with HP-positive.

 Therefore, at present the majority of experts believe that, HP is the main reason for peptic ulcer, other well, such as smoking, alcohol, (the damage to the stomach) drugs, bile reflux and other secondary factors.

Next Article: Bad habits lead to ulcers

Comments

Leave a Reply