Points A, B-type atrophic gastritis
Department of atrophic gastritis type A autoimmune diseases, auto-antibodies. Because autoimmune injury occurred in the parietal cells, and therefore heavier lesions to the gastric body, gastric body glands have been destroyed, but the contraction, it significantly reduced gastric acid secretion or acid-free and, therefore, caused by increased serum gastrin level in the last can develop into gastric atrophy.
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According to the site of atrophic gastritis with immunological changes, including auto-immune tests and serum gastrin measured, Strick land will be divided into atrophic gastritis, A, B two types.
Department of atrophic gastritis type A autoimmune diseases, auto-antibodies. Because autoimmune injury occurred in the parietal cells, and therefore heavier lesions to the gastric body, gastric body glands have been destroyed, but the contraction, it significantly reduced gastric acid secretion or acid-free and, therefore, caused by increased serum gastrin level in the last can develop into gastric atrophy. Food VitB12 with wall cells to secrete the intrinsic factor (IF) combined into intrinsic factor vitamin B12 complex, it helps the absorption of Vit B12. In the A-type atrophic gastritis can be found in serum of patients with intrinsic factor antibodies (IFA), mainly IgG, a combination of the sub-type and block type. IFA can be conjugated with the intrinsic factor or intrinsic factor vitamin B12 complex combination of blocking and the blocking-based IFA combination of intrinsic factor and vitamin B12, which affects the absorption of vitamin B12. -A in patients with pernicious anemia often accompanied (16%), of which 60% of pernicious anemia are blocked based IFA. Atrophic gastritis in China were mainly seen in the gastric antrum, body occurs in the stomach and few, which is consistent with our little pernicious anemia.
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B-type atrophic gastritis is not immune diseases, autoantibodies were negative. The incidence of reflux with duodenal fluid, or other chemical, physical damage related to gastric mucosa of gastric mucosal permeability than the stronger (H + reverse diffusion capacity of gastric antrum was stronger than the bottom 20 times). As the antral mucosal barrier effects than other parts of the small, to be susceptible to duodenal contents reflux liquid and its impact, it most likely involved antrum. The body of stomach lesions of light, so the normal gastric acid secretion. Lesions damaged the gastric antrum G-cells in pyloric glands, gastrin secretion reduced, so the general low level of serum gastrin. Cancer with atrophic gastritis type B dominated, the cancer process can be as long as 10 years or more.
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