Simple causes of acute gastritis
Acute Simple Gastritis etiology and pathogenesis of
1, infection factors, consumption by bacteria or their toxins contaminated food. Common pathogenic bacteria Salmonella Vibrio parahaemolyticus (halophilic bacteria) Helicobacter pylori, and certain influenza viruses and enteric viruses. Toxin in Staphylococcus aureus toxin is the most common. Salmonella is often meat, and eggs grow. Vibrio parahaemolyticus, mainly in crabs, fish, snails, jellyfish and other seafood, pickles in the hot, long home meals, milk, meat suitable for breeding and staphylococcal enterotoxin production.
Second, physical and chemical factors, physical factors such as the consumption of heat, cold rough food, X-ray radiation and so on. Chemical factors, such as spirits, coffee, tea, spices and certain drugs can damage gastric mucosa, causing inflammatory changes.
3, other eating and drinking, fatigue, cold, etc. to make the body resistant to degradation or destruction of mucosal barriers, vulnerable to attack while the incidence of the above factors.
Acute gastric mucosal lesions in the etiology and pathogenesis
1, drug multiple drugs, a common non-steroidal anti-inflammatory drugs such as aspirin, indomethacin, phenylbutazone, etc., as well as the adrenal cortex hormones. Aspirin in the acidic environment was non-ionic and relative fat-soluble, can damage the gastric mucosal layer of epithelial cells, lipoproteins, weakened mucosal barrier against the penetration of hydrogen ions caused to the mucosa, causing inflammatory exudation, edema, erosion, hemorrhage or shallow ulcers. Adrenal cortex hormones can cause “steroid ulcer,” and even perforation, and gastric acid, protease secretion, gastric mucus secretion decreased, reducing mucosal barrier, inhibit regeneration of the gastric epithelial cells. Other drugs, such as snakeroot agents, digitalis, antibiotics, potassium salt, caffeine, etc. can also be caused by the disease.
2, alcoholism is also a common cause of this disease. After a large number of alcohol cause acute gastric mucosal erosion and hemorrhage. Ethanol soluble lipoprotein gastric epithelial layer, or ethanol through the blood damage the cervical mucus gland cells, so that reduction of gastric mucus, which can cause gastric mucosal barrier damage, resulting in penetration of hydrogen ions against the inflammation caused by leakage, bleeding, ulcers, collectively referred to as stress ulcer. In stress cases, ACTH, corticotropin releasing a large number, a significant increase in gastric secretion, gastric mucus decreased mucous cells reduced DNA synthesis, on the other through the autonomic nerves to mucosal vascular spasm, combined with inadequate blood volume, so that reduction of gastric mucosal blood flow , hypoxia, energy metabolism are affected, lesions at the mast cells to release histamine and 5 – HT and other active substances, so that local vasodilatation, exudation, edema, and further excited to a large number of parietal cell H2 receptors of gastric acid secretion, leading to the stomach mucosal erosion, the formation of ulcers.
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